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O-methyl-bufotenin, also known as 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), is a member of the tryptamine family of psychedelics. Numerous plant species contain it, and at least one toad species—the Colorado River toad—also produces it in its glands. It has been utilized as an entheogen in South America, along with its close relatives DMT and bufotenin (5-HO-DMT). Five-methoxy, the power, bufo, and toad venom are slang phrases.

Effects 5-MeO-DMT

Depending on whether you smoked it or inhaled it, the overall experience might last anywhere from 10 minutes to 2 hours. Effects can vary widely and include dysphoria, anxiety, horror, and panic as well as dramatic viewpoint shifting and the feeling of new insights, euphoria, immersive experiences, dissociation and non-responsiveness, amplification of the sensuous and erotic, and dysphoria.


Uses 5-MeO-DMT

It has anti-anxiety and anti-depressant effects.

Religious use The Church of the Tree of Life, founded in California in 1971 by John Mann but now defunct, declared the use of 5-MeO-DMT to be a sacrament. From approximately 1971 to the late 1980s,was discreetly available to its members. Between 1970 and 1990, smoking of 5-MeO-DMT on parsley was probably one of the two most common forms of ingestion in the United States.


DMT has a methoxylated derivative called 5-MeO-DMT. While the majority of commonly used psychedelics are thought to primarily have psychological effects by agonizing serotonin 5-HT2A receptors, has a 1000-fold higher affinity for 5-HT1A receptors than 5-HT2AIn accordance with this affinity, 5-MeO-DMT has a very strong inhibitory effect on the firing of dorsal raphe 5-HT neurons.

Additionally, the 5-HT1A selective antagonist WAY-100635 reduced its action in rats, whereas the 5-HT2A selective antagonist volinanserin had no effect. There may also be additional modes of action, such as suppression of monoamine reuptake. Inhaling once resulted in a continuous improvement in life satisfaction as well as a reduction in anxiety, depression, and post-traumatic stress disorder (PTSD), according to a 2019 European study with 42 participants.

Additional information


1.5 gram, 10 grams, 20 grams, 25 grams, 3 grams, 5 grams


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